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Ralph Meyer

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Animal, Dairy & Vet Sciences

Pharmacology/Toxicology, Reproductive Biology, Epigenetics

Associate Professor

Contact Information

Go toOffice Location: AGRS 247
DialPhone: 435-797-1774

Educational Background

PhD, Molecular Cell Biology, University of Kaiserslautern, 1998
Poly(ADP-ribose) metabolism in DNA repair and carcinogenesis
Molecular Cell Biology, (Botany, Biochemistry), University of Kaiserslautern, 1994
Methods for regeneration and transformation of the bean "Phaseolus vulgaris"


US citizen, PhD in Molecular Cell Biology (PhD, Univ. Kaiserslautern, DKFZ Heidelberg, Germany). Postdoctoral training, Molecular Toxicology (Tuebingen, Tucson). Faculty, SVM, University of Pennsylvania. Associate Dept. Head for SVM, USU.

Teaching Interests

VM7522-Fundamentals of Pharmacology (course director), VM7523 - Toxicology

Research Interests

Reproductive toxicology, developmental biology


Biology of Reproduction Top Reviewing Editor of 2017, 2018

Society for the Study of Reproduction

Edward A. Smuckler Memorial AACR Poster, 2004

American Association for Cancer Research, AACR

Travel Award, 2004

53rd Annual Fujihara Seminar, Tomakomai, Hokkaido, Japan.

NIH Ruth-Kirschstein-NRSA fellowship (T32, 2002-2004), 2002

National Institutes of Health

Publications - Abstracts

    Publications - Books & Book Chapters

      Book Chapters

    • Meyer-Ficca, M., Meyer, R., (2019). Epigenetic Changes in the Paternal Germline: Transgenerational Epigenetics, 2nd Edition. Elsevier Academic Press
    • Meyer, R., Meyer-Ficca, M., Jacobson, E.L, Jacobson, M.K, (2004). Enzymes in poly(ADP-ribose) metabolism: Poly(ADP-ribosyl)ation. Landes Bioscience

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    Publications - Fact Sheets

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      Publications - Curriculum

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        Publications - Journal Articles

          Academic Journal

        • Cacciolatti, C., Meyer-Ficca, M., Southwood, L.L, Meyer, R., Bertolotti, L., Zarucco, L., (2019). In-vitro effects of poly(ADP-Ribose) polymerase inhibitors in an equine model of inflammation. American Journal of Veterinary Research , 80:7, 663-669. doi: DOI: 10.2460/ajvr.80.7.663
        • Palzer, L., Bader, J.J, Angel, F., Witzel, M., Blaser, S., McNeil, A., Wandersee, M.K, Leu, N.A, Lengner, C.J, Cho, C.E, Welch, K.D, Kirkland, J.B, Meyer, R., Meyer-Ficca, M., (2018). Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis. Cell Reports, 25:5, 1359-1370. doi: doi: 10.1016/j.celrep.2018.09.091
        • Ketchum, C.C, Larsen, C.D, McNeil, A., Meyer-Ficca, M., Meyer, R., (2018). Early Histone H4 Acetylation during Chromatin Remodeling in Equine Spermatogenesis. , 98:1, 115-129. doi:
        • Meyer, R., Ketchum, C.C, Meyer-Ficca, M., (2017). Heritable Sperm Chromatin Epigenetics: A Break to Remember. Biology of Reproduction, 97:6, 787-797. doi:
        • Douglas, H.F, Southwood, L.L, Meyer-Ficca, M., Hart, S.K, Meyer, R., (2015). The activity and inhibition of poly(ADP-ribose) polymerase-1 in equine peripheral blood mononuclear cells in vitro. , 25:4, 528-37. doi: doi: 10.1111/vec.12316
        • Bryant, J.M, Donahue, G., Wang, X., Meyer-Ficca, M., Luense, L.J, Weller, A.H, Bartolomei, M.S, Blobel, G.A, Meyer, R., Garcia, B.A, Berger, S.L, (2015). Characterization of BRD4 during mammalian postmeiotic sperm development.. Molecular and cellular biology, 35:8, 1433-48.
        • Meyer-Ficca, M., Ihara, M., Bader, J.J, Leu, N.A, Beneke, S., Meyer, R., (2015). Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice.. Biology of reproduction, 92:3, 80.
        • Ihara, M., Meyer-Ficca, M., Leu, N.A, Rao, S., Li, F., Gregory, B.D, Zalenskaya, I.A, Schultz, R.M, Meyer, R., (2014). Paternal poly(ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression. PLOS Genetics, doi: 10.1371/journal.pgen.1004317
        • Bryant, J.M, Meyer-Ficca, M., Dang, V.M, Berger, S.L, Meyer, R., (2013). Separation of spermatogenic cell types using STA-PUT velocity sedimentation. J Vis Exp80
        • Meyer-Ficca, M., Lonchar, J.D, Ihara, M., Bader, J.J, Meyer, R., (2013). Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma, 122:4, 319–335.
        • Meyer-Ficca, M., Meyer, R., (2011). Genetic approaches to targeting multiple PARP genes in a mammalian genome. Methods Mol. Biol., 780, 349–376.
        • Bermudez, Y., Benavente, C.A, Meyer, R., Coyle, W.R, Jacobson, M.K, Jacobson, E.L, (2011). Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. PLoS ONE, 6:5, e20487.
        • Meyer-Ficca, M., Lonchar, J.D, Ihara, M., Meistrich, M.L, Austin, C.A, Meyer, R., (2011). Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol. Reprod., 84:5, 900–909.
        • Meyer-Ficca, M., Ihara, M., Lonchar, J.D, Meistrich, M.L, Austin, C.A, Min, W., Wang, Z.Q, Meyer, R., (2011). Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol. Reprod., 84:2, 218–228.
        • Whatcott, C.J, Meyer-Ficca, M., Meyer, R., Jacobson, M.K, (2009). A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp. Cell Res., 315:20, 3477–3485.
        • Meyer-Ficca, M., Lonchar, J., Credidio, C., Ihara, M., Li, Y., Wang, Z.Q, Meyer, R., (2009). Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol. Reprod., 81:1, 46–55.
        • Meyer, R., Meyer-Ficca, M., Whatcott, C.J, Jacobson, E.L, Jacobson, M.K, (2007). Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Exp. Cell Res., 313:13, 2920–2936.
        • Gao, H., Coyle, D.L, Meyer-Ficca, M., Meyer, R., Jacobson, E.L, Wang, Z.Q, Jacobson, M.K, (2007). Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Exp. Cell Res., 313:5, 984–996.
        • Meyer-Ficca, M., Meyer, R., Jacobson, E.L, Jacobson, M.K, (2005). Poly(ADP-ribose) polymerases: managing genome stability. Int. J. Biochem. Cell Biol., 37:5, 920–926.
        • Meyer-Ficca, M., Scherthan, H., Burkle, A., Meyer, R., (2005). Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma, 114:1, 67–74.
        • Meyer-Ficca, M., Meyer, R., Kaiser, H., Brack, A.R, Kandolf, R., Kupper, J.H, (2004). Comparative analysis of inducible expression systems in transient transfection studies. Anal. Biochem., 334:1, 9–19.
        • Cortes, U., Tong, W.M, Coyle, D.L, Meyer-Ficca, M., Meyer, R., Petrilli, V., Herceg, Z., Jacobson, E.L, Jacobson, M.K, Wang, Z.Q, (2004). Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol. Cell. Biol., 24:16, 7163–7178.
        • Meyer, R., Meyer-Ficca, M., Kaiser, H., Selinka, H.C, Kandolf, R., Kupper, J.H, (2004). Plasmid-based generation of recombinant coxsackievirus B3 particles carrying capsid gene replacement replicons. Virus Res., 104:1, 17–26.
        • Meyer-Ficca, M., Meyer, R., Coyle, D.L, Jacobson, E.L, Jacobson, M.K, (2004). Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Exp. Cell Res., 297:2, 521–532.
        • Grassi, G., Maccaroni, P., Meyer, R., Kaiser, H., D’Ambrosio, E., Pascale, E., Grassi, M., Kuhn, A., Di Nardo, P., Kandolf, R., Kupper, J.H, (2003). Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. Carcinogenesis, 24:10, 1625–1635.
        • Meyer, R., Meyer-Ficca, M., Jacobson, E.L, Jacobson, M.K, (2003). Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23). Gene, 314, 181–190.
        • Brabeck, C., Pfeiffer, R., Leake, A., Beneke, S., Meyer, R., Burkle, A., (2003). L-selegiline potentiates the cellular poly(ADP-ribosyl)ation response to ionizing radiation. J. Pharmacol. Exp. Ther., 306:3, 973–979.
        • Burkle, A., Beneke, S., Brabeck, C., Leake, A., Meyer, R., Muiras, M.L, Pfeiffer, R., (2002). Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity. Exp. Gerontol., 37:10-11, 1203–1205.
        • Meyer, R., Kupper, J.H, Kandolf, R., Rodemann, H.P, (2002). Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. Eur. J. Biochem., 269:1, 337–346.
        • Meyer, R., Muller, M., Beneke, S., Kupper, J.H, Burkle, A., (2000). Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity. Int. J. Cancer, 88:3, 351–355.
        • Beneke, S., Meyer, R., Burkle, A., (1997). Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly (ADP-ribose) polymerase. Biochem. Mol. Biol. Int., 43:4, 755–761.
        • Van Gool, L., Meyer, R., Tobiasch, E., Cziepluch, C., Jauniaux, J.C, Mincheva, A., Lichter, P., Poirier, G.G, Burkle, A., Kupper, J.H, (1997). Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation. Eur. J. Biochem., 244:1, 15–20.
        • Meyer, R., Nagl, W., (1993). Endopolyploidy in the extraembryonic membranes of the snake, Elaphe guttata. Protoplasma172, 132-135. doi: 10.1007/BF01379370
        • Professional Journal

        • Meyer, R., Meyer-Ficca, M., Kupper, J., (2016). Adenoviral vectors for modulation of poly(ADP-ribose) polymerase-1 (PARP1) – dependent DNA repair as a predictive tool for chemotherapy. Journal of Cellular Biotechnology / IOS Press, 2:1, 57-68. doi: DOI 10.3233/JCB-15026

        * Has not been peer reviewed

        Publications - Literary Journal

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          Publications - MultiMedia

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            Publications - Technical Reports

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              Publications - Translations & Transcripts

                Publications - Other

                  * Has not been peer reviewed

                  Scheduled Teaching

                  VM 7523 - Veterinary Toxicology, Spring 2022

                  VM 7522 - Fundamentals of Pharmacology, Fall 2021

                  VM 7523 - Veterinary Toxicology, Spring 2021

                  VM 7522 - Fundamentals of Pharmacology, Fall 2020

                  VM 7523 - Veterinary Toxicology, Spring 2020

                  VM 7522 - Fundamentals of Pharmacology, Fall 2019

                  VM 7522 - Fundamentals of Pharmacology, Fall 2018

                  VM 7522 - Fundamentals of Pharmacology, Fall 2017

                  VM 7523 - Veterinary Toxicology, Spring 2017

                  VM 7522 - Fundamentals of Pharmacology, Fall 2016

                  VM 7523 - Veterinary Toxicology, Spring 2016

                  VM 7522 - Fundamentals of Pharmacology, Fall 2015

                  VM 7523 - Veterinary Toxicology, Spring 2015

                  VM 7522 - Fundamentals of Pharmacology, Fall 2014

                  VM 7523 - Veterinary Toxicology, Spring 2014

                  VM 7522 - Fundamentals of Pharmacology, Fall 2013

                  Graduate Students Mentored

                  Renata Hoskova, Animal, Dairy & Vet Sciences, July 2020
                  Renata Hoskova, Animal, Dairy & Vet Sciences, August 2020 - September 2021
                  Chelsea Ketchum, Animal, Dairy & Vet Sciences, September 2015 - June 2017