Faculty | VetMed
Ralph Meyer

Animal, Dairy & Vet Sciences
Pharmacology/Toxicology, Reproductive Biology, Epigenetics
Associate Professor
Contact Information
Go toOffice Location: AGRS 247
DialPhone: 435-797-1774
SendEmail: ralph.meyer@usu.edu
Educational Background
PhD, Molecular Cell Biology, University of Kaiserslautern, 1998 Dissertation
Poly(ADP-ribose) metabolism in DNA repair and carcinogenesis
Biography
US citizen, PhD in Molecular Cell Biology (PhD, Univ. Kaiserslautern, DKFZ Heidelberg, Germany). Postdoctoral training, Molecular Toxicology (Tuebingen, Tucson). Faculty, SVM, University of Pennsylvania. Associate Dept. Head for SVM, USU.
Teaching Interests
VM7522-Fundamentals of Pharmacology (course director),
VM7523 - Toxicology
Research Interests
Reproductive toxicology, developmental biology
Awards
Biology of Reproduction Top Reviewing Editor of 2017, 2018
Society for the Study of ReproductionEdward A. Smuckler Memorial AACR Poster, 2004
American Association for Cancer Research, AACRTravel Award, 2004
53rd Annual Fujihara Seminar, Tomakomai, Hokkaido, Japan.NIH Ruth-Kirschstein-NRSA fellowship (T32, 2002-2004), 2002
National Institutes of HealthPublications - Abstracts
Publications - Books & Book Chapters
- Meyer-Ficca, M., Meyer, R., (2019). Epigenetic Changes in the Paternal Germline: Transgenerational Epigenetics, 2nd Edition. Elsevier Academic Press
- Meyer, R., Meyer-Ficca, M., Jacobson, E.L, Jacobson, M.K, (2004). Enzymes in poly(ADP-ribose) metabolism: Poly(ADP-ribosyl)ation. Landes Bioscience
Book Chapters
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Publications - Fact Sheets
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Publications - Curriculum
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Publications - Journal Articles
- Cacciolatti, C., Meyer-Ficca, M., Southwood, L.L, Meyer, R., Bertolotti, L., Zarucco, L., (2019). In-vitro effects of poly(ADP-Ribose) polymerase inhibitors in an equine model of inflammation. American Journal of Veterinary Research , 80:7, 663-669. doi: DOI: 10.2460/ajvr.80.7.663
- Palzer, L., Bader, J.J, Angel, F., Witzel, M., Blaser, S., McNeil, A., Wandersee, M.K, Leu, N.A, Lengner, C.J, Cho, C.E, Welch, K.D, Kirkland, J.B, Meyer, R., Meyer-Ficca, M., (2018). Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis. Cell Reports, 25:5, 1359-1370. doi: doi: 10.1016/j.celrep.2018.09.091
- Ketchum, C.C, Larsen, C.D, McNeil, A., Meyer-Ficca, M., Meyer, R., (2018). Early Histone H4 Acetylation during Chromatin Remodeling in Equine Spermatogenesis. , 98:1, 115-129. doi: https://doi.org/10.1093/biolre/iox159
- Meyer, R., Ketchum, C.C, Meyer-Ficca, M., (2017). Heritable Sperm Chromatin Epigenetics: A Break to Remember. Biology of Reproduction, 97:6, 787-797. doi: https://doi.org/10.1093/biolre/iox137
- Douglas, H.F, Southwood, L.L, Meyer-Ficca, M., Hart, S.K, Meyer, R., (2015). The activity and inhibition of poly(ADP-ribose) polymerase-1 in equine peripheral blood mononuclear cells in vitro. , 25:4, 528-37. doi: doi: 10.1111/vec.12316
- Bryant, J.M, Donahue, G., Wang, X., Meyer-Ficca, M., Luense, L.J, Weller, A.H, Bartolomei, M.S, Blobel, G.A, Meyer, R., Garcia, B.A, Berger, S.L, (2015). Characterization of BRD4 during mammalian postmeiotic sperm development.. Molecular and cellular biology, 35:8, 1433-48.
- Meyer-Ficca, M., Ihara, M., Bader, J.J, Leu, N.A, Beneke, S., Meyer, R., (2015). Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice.. Biology of reproduction, 92:3, 80.
- Ihara, M., Meyer-Ficca, M., Leu, N.A, Rao, S., Li, F., Gregory, B.D, Zalenskaya, I.A, Schultz, R.M, Meyer, R., (2014). Paternal poly(ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression. PLOS Genetics, doi: 10.1371/journal.pgen.1004317
- Bryant, J.M, Meyer-Ficca, M., Dang, V.M, Berger, S.L, Meyer, R., (2013). Separation of spermatogenic cell types using STA-PUT velocity sedimentation. J Vis Exp80
- Meyer-Ficca, M., Lonchar, J.D, Ihara, M., Bader, J.J, Meyer, R., (2013). Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma, 122:4, 319–335.
- Meyer-Ficca, M., Meyer, R., (2011). Genetic approaches to targeting multiple PARP genes in a mammalian genome. Methods Mol. Biol., 780, 349–376.
- Bermudez, Y., Benavente, C.A, Meyer, R., Coyle, W.R, Jacobson, M.K, Jacobson, E.L, (2011). Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. PLoS ONE, 6:5, e20487.
- Meyer-Ficca, M., Lonchar, J.D, Ihara, M., Meistrich, M.L, Austin, C.A, Meyer, R., (2011). Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol. Reprod., 84:5, 900–909.
- Meyer-Ficca, M., Ihara, M., Lonchar, J.D, Meistrich, M.L, Austin, C.A, Min, W., Wang, Z.Q, Meyer, R., (2011). Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol. Reprod., 84:2, 218–228.
- Whatcott, C.J, Meyer-Ficca, M., Meyer, R., Jacobson, M.K, (2009). A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp. Cell Res., 315:20, 3477–3485.
- Meyer-Ficca, M., Lonchar, J., Credidio, C., Ihara, M., Li, Y., Wang, Z.Q, Meyer, R., (2009). Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol. Reprod., 81:1, 46–55.
- Meyer, R., Meyer-Ficca, M., Whatcott, C.J, Jacobson, E.L, Jacobson, M.K, (2007). Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Exp. Cell Res., 313:13, 2920–2936.
- Gao, H., Coyle, D.L, Meyer-Ficca, M., Meyer, R., Jacobson, E.L, Wang, Z.Q, Jacobson, M.K, (2007). Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Exp. Cell Res., 313:5, 984–996.
- Meyer-Ficca, M., Meyer, R., Jacobson, E.L, Jacobson, M.K, (2005). Poly(ADP-ribose) polymerases: managing genome stability. Int. J. Biochem. Cell Biol., 37:5, 920–926.
- Meyer-Ficca, M., Scherthan, H., Burkle, A., Meyer, R., (2005). Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma, 114:1, 67–74.
- Meyer-Ficca, M., Meyer, R., Kaiser, H., Brack, A.R, Kandolf, R., Kupper, J.H, (2004). Comparative analysis of inducible expression systems in transient transfection studies. Anal. Biochem., 334:1, 9–19.
- Cortes, U., Tong, W.M, Coyle, D.L, Meyer-Ficca, M., Meyer, R., Petrilli, V., Herceg, Z., Jacobson, E.L, Jacobson, M.K, Wang, Z.Q, (2004). Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol. Cell. Biol., 24:16, 7163–7178.
- Meyer, R., Meyer-Ficca, M., Kaiser, H., Selinka, H.C, Kandolf, R., Kupper, J.H, (2004). Plasmid-based generation of recombinant coxsackievirus B3 particles carrying capsid gene replacement replicons. Virus Res., 104:1, 17–26.
- Meyer-Ficca, M., Meyer, R., Coyle, D.L, Jacobson, E.L, Jacobson, M.K, (2004). Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Exp. Cell Res., 297:2, 521–532.
- Grassi, G., Maccaroni, P., Meyer, R., Kaiser, H., D’Ambrosio, E., Pascale, E., Grassi, M., Kuhn, A., Di Nardo, P., Kandolf, R., Kupper, J.H, (2003). Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. Carcinogenesis, 24:10, 1625–1635.
- Meyer, R., Meyer-Ficca, M., Jacobson, E.L, Jacobson, M.K, (2003). Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23). Gene, 314, 181–190.
- Brabeck, C., Pfeiffer, R., Leake, A., Beneke, S., Meyer, R., Burkle, A., (2003). L-selegiline potentiates the cellular poly(ADP-ribosyl)ation response to ionizing radiation. J. Pharmacol. Exp. Ther., 306:3, 973–979.
- Burkle, A., Beneke, S., Brabeck, C., Leake, A., Meyer, R., Muiras, M.L, Pfeiffer, R., (2002). Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity. Exp. Gerontol., 37:10-11, 1203–1205.
- Meyer, R., Kupper, J.H, Kandolf, R., Rodemann, H.P, (2002). Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. Eur. J. Biochem., 269:1, 337–346.
- Meyer, R., Muller, M., Beneke, S., Kupper, J.H, Burkle, A., (2000). Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity. Int. J. Cancer, 88:3, 351–355.
- Beneke, S., Meyer, R., Burkle, A., (1997). Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly (ADP-ribose) polymerase. Biochem. Mol. Biol. Int., 43:4, 755–761.
- Van Gool, L., Meyer, R., Tobiasch, E., Cziepluch, C., Jauniaux, J.C, Mincheva, A., Lichter, P., Poirier, G.G, Burkle, A., Kupper, J.H, (1997). Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation. Eur. J. Biochem., 244:1, 15–20.
- Meyer, R., Nagl, W., (1993). Endopolyploidy in the extraembryonic membranes of the snake, Elaphe guttata. Protoplasma172, 132-135. doi: 10.1007/BF01379370
- Meyer, R., Meyer-Ficca, M., Kupper, J., (2016). Adenoviral vectors for modulation of poly(ADP-ribose) polymerase-1 (PARP1) – dependent DNA repair as a predictive tool for chemotherapy. Journal of Cellular Biotechnology / IOS Press, 2:1, 57-68. doi: DOI 10.3233/JCB-15026
Academic Journal
Professional Journal
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Publications - Literary Journal
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Publications - MultiMedia
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Publications - Technical Reports
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Publications - Translations & Transcripts
Publications - Other
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Scheduled Teaching
VM 7523 - Veterinary Toxicology, Spring 2022
VM 7522 - Fundamentals of Pharmacology, Fall 2021
VM 7523 - Veterinary Toxicology, Spring 2021
VM 7522 - Fundamentals of Pharmacology, Fall 2020
VM 7523 - Veterinary Toxicology, Spring 2020
VM 7522 - Fundamentals of Pharmacology, Fall 2019
VM 7522 - Fundamentals of Pharmacology, Fall 2018
VM 7522 - Fundamentals of Pharmacology, Fall 2017
VM 7523 - Veterinary Toxicology, Spring 2017
VM 7522 - Fundamentals of Pharmacology, Fall 2016
VM 7523 - Veterinary Toxicology, Spring 2016
VM 7522 - Fundamentals of Pharmacology, Fall 2015
VM 7523 - Veterinary Toxicology, Spring 2015
VM 7522 - Fundamentals of Pharmacology, Fall 2014
VM 7523 - Veterinary Toxicology, Spring 2014
VM 7522 - Fundamentals of Pharmacology, Fall 2013
Graduate Students Mentored
Renata Hoskova, Animal, Dairy & Vet Sciences, July 2020
Renata Hoskova, Animal, Dairy & Vet Sciences, August 2020 - September 2021
Chelsea Ketchum, Animal, Dairy & Vet Sciences, September 2015 - June 2017