Brett Hurst

Publications | Abstracts

• Rowley, K.J, Singh, V., Roberts, A., Heang, K.A, Venkatasubramanian, P.B, Konakondla, J.V, Fared, D., Lu, M., Hurst, B.L, Hancock, W.W, Babcock, G.J, Robinson, L.N, (2025). #1035 Differential impacts of APRIL and APRIL/BAFF inhibition on immune populations: implications for IgAN treatment and protective immunity. Nephrology Dialysis Transplantation *

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

• Hurst, B., Julander, J., Wang, H., (2025). Structure-Activity Relationship Studies Towards Analogues of Pleconaril as Novel Enterovirus-D68 Capsid-Targeting Antivirals.. bioRxiv : the preprint server for biology, doi: 10.1101/2025.08.08.668114
• Tuttle, J.B, Allais, C., Allerton, C.M, Anderson, A.S, Arcari, J.T, Aschenbrenner, L.M, Avery, M., Bellenger, J., Berritt, S., Boras, B., Boscoe, B.P, Buzon, L.M, Cardin, R.D, Carlo, A.A, Coffman, K.J, Dantonio, A., Di, L., Eng, H., Farley, K.A, Ferre, R.A, Gajiwala, K.S, Gibson, S.A, Greasley, S.E, Hurst, B.L, Kadar, E.P, Kalgutkar, A.S, Lachapelle, E.A, Lanyon, L.F, Lee, J., Lee, J., Lian, Y., Liu, W., Martinez-Alsina, L.A, Mason, S.W, Noell, S., Novak, J., Obach, R.S, Ogilvie, K., O'Neil, S.V, Ostner, G., Owena, D.R, Patel, N.C, Petterson, M., Singh, R.S, Rai, D.K, Reese, M.R, Sakata, S., Sammons, M.F, Sathish, J.G, Sharma, R., Steppan, C.M, Stewart, A., Updyke, L., Verhoest, P.R, Wei, L., Wright, S.W, Yang, E., Yang, Q., Zhu, Y., (2025). Discovery of Nirmatrelvir (PF-07321332): A Potent Orally Active Inhibitor of the Severe Cute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease. Journal of Medicinal Chemistry, doi: 10.1021/acs.jmedchem.4c02561
• Gibson, S.A, Liu, Y., Li, R., Hurst, B., Fan, Z., Siddharthan, V., Larson, D.P, Sheesley, A.Y, Stewart, R., Kunzler, M., Polejaeva, I., Van Wettere, A., Moisyadi, S., Morrey, J.D, Tarbet, B., Wang, Z., (2024). Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines. Viruses, 16:10, doi: 10.3390/v16101625
• Garnsey, M.R, Robinson, M.C, Nguyen, L.T, Cardin, R., Tillotson, J., Mashalidis, E., Yu, A., Aschenbrenner, L., Balesano, A., Behzadi, A., Boras, B., Chang, J.S, Eng, H., Ephron, A., Foley, T., Ford, K.K, Frick, J.M, Gibson, S.A, Hao, L., Hurst, B.L, Kalgutkar, A.S, Korczynska, M., Lengyel-Zhand, Z., Gao, L., Meredith, H.R, Patel, N.C, Polivkova, J., Rai, D., Rose, C.R, Rothan, H., Sakata, S.K, Vargo, T.R, Qi, W., Wu, H., Liu, Y., Yurgelonis, I., Zhang, J., Zhu, Y., Zhang, L., Lee, A.A, (2024). Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model. Science Advances, 10:35, doi: 10.1126/sciadv.ado4288
• Leekha, A., Saeedi, A., Sefat, K.M, Kumar, M., Martinez-Paniagua, M., Damian, A., Kulkarni, R., Reichel, K., Rezvan, A., Masoumi, S., Liu, X., Cooper, L.J, Sebastian, M., Sands, C.M, Das, V.E, Patel, N.B, Hurst, B.L, Varadarajan, N., (2024). Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters. Nature Communications, 15:1, doi: 10.1038/s41467-024-50133-2
• Hurst, B., (2024). An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models. Nature Communications, 15, doi: 10.1038/s41467-024-50234-y
• Gibson, S.A, Hurst, B.L, (2024). A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19. Journal of Medicinal Chemistry, doi: 10.1021/acs.jmedchem.3c02469
• Spengler, J.R, Carter, K., Delang, L., Durantel, D., Gowen, B.B, Herrero, L.J, Hurst, B.L, Janeba, Z., Jordan, R., Luo, D., Meier, C., Moffat, J., Rocha-Pereira, J., Seley-Radtke, K.L, Welch, S.R, Schang, L.M, (2023). Meeting report: 36th International Conference on Antiviral Research in Lyon, France – March 13–17, 2023. Antiviral Research, 217, 105678. doi: 10.1016/j.antiviral.2023.105678
• Honda-Okubo, Y., Sakala, I.G, Andre, F., Tarbet, B., Hurst, B., Petrovsky, N., (2023). An Advax-CpG55.2 adjuvanted recombinant hemagglutinin vaccine provides immunity against H7N9 influenza in adult and neonatal mice. Vaccine, 5592-5602. doi: 10.1016/j.vaccine.2023.07.061
• Lane, T.R, Fu, J., Sherry, B., Tarbet, B., Hurst, B., Riabova, O., Kazakova, E., Egorova, A., Clarke, P., Leser, J.S, Frost, J., Rudy, M., Tyler, K.L, Klose, T., Volobueva, A.S, Velyaevskaya, S.V, Zarubaev, V.V, Kuhn, R.J, Makarov, V., Ekins, S., (2023). Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5. Antiviral Research, doi: 10.1016/j.antiviral.2023.105654
• Spengler, J.R, Carter, K., Delang, L., Durantel, D., Gowen, B., Herrero, L.J, Hurst, B., Janeba, Z., Jordan, R., Luo, D., Meier, C., Moffat, J., Rocha-Pereira, J., Seley-Radtke, K.L, Welch, S.R, Schang, L.M, (2023). Meeting report: 36th International Conference on Antiviral Research in Lyon, France - March 13-17, 2023. Antiviral Research, 217, 105678. doi: https://doi.org/10.1016/j.antiviral.2023.105678
• Peterson, C.J, Hurst, B., Evans, W., Van Wettere, A., Gibson, S.A, Smee, D.F, Tarbet, B., (2023). Human IVIG treatment in a neurological disease model for Enterovirus A71 infection in 28-day-old AG129 mice. Virology580, 62-72. doi: 10.1016/j.virol.2023.02.002
• Owen, D.R, Allerton, C.M, Anderson, A.S, Aschenbrenner, L., Avery, M., Berritt, S., Boras, B., Cardin, R.D, Carlo, A., Coffman, K.J, Dantonio, A., Di, L., Eng, H., Ferre, R., Gajiwala, K.S, Gibson, S.A, Greasley, S.E, Hurst, B.L, Kadar, E.P, Kalgutkar, A.S, Lee, J.C, Lee, J., Liu, W., Mason, S.W, Noell, S., Novak, J.J, Obach, R.S, Ogilvie, K., Patel, N.C, Petterson, M., Rai, D.K, Reese, M.R, Sammons, M.F, Sathish, J.G, Singh, R.S, Steppan, C.M, Stewart, A.E, Tuttle, J.B, Updyke, L., Verhoest, P.R, Wei, L., Yang, Q., Zhu, Y., (2021). An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19. Science, 374:6575, 1586-1593. doi: 10.1126/science.abl4784
• Gawriljuk, V.O, Zin, P.P, Puhl, A.C, Zorn, K.M, Foil, D.H, Lane, T.R, Hurst, B.L, Tavella, T.A, Costa, F.T, Lakshmanane, P., Bernatchez, J., Godoy, A.S, Oliva, G., Siqueira-Neto, J.L, Madrid, P.B, Ekins, S., (2021). Machine Learning Models Identify Inhibitors of SARS-CoV-2. Journal of Chemical Information and Modeling, 61:9, 4224-4235. doi: 10.1021/acs.jcim.1c00683
• Reynolds, D., Huesemann, M., Edmundson, S., Sims, A., Hurst, B.L, Cady, S., Beirne, N., Freeman, J., Berger, A., Gao, S., (2021). Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis. Algal Research, 57, 102331. doi: 10.1016/j.algal.2021.102331
• Arroyo, R., Grant, S.N, Colombo, M., Salvioni, L., Corsi, F., Truffi, M., Ottolina, D., Hurst, B.L, Salzberg, M., Prosperi, D., Kingma, P.S, (2021). Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2. Biomolecules, 11:8, 1114. doi: 10.3390/biom11081114
• Hahn, F., Wangen, C., Häge, S., Peter, A.S, Dobler, G., Hurst, B.L, Julander, J.G, Fuchs, J., Ruzsics, Z., Überla, K., Jäck, H., Ptak, R., Muehler, A., Gröppel, M., Vitt, D., Peelen, E., Kohlhof, H., Marschall, M., (2020). IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro. Viruses, 12:12, 1394. doi: 10.3390/v12121394

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

Other

• Gilliam, E., Mason, J., Page, C.M, Hurst, B., (2025). Micro-CT Evaluation of Bone Changes in Osteoarthritic Sheep Treated With Gene Therapy via TIMP-3. Digital commons USU

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.