Arnaud Van Wettere

Publications | Abstracts

• Perisse, I.V, Fan, Z., Liu, Y., Vaghela, N., Patrick, T., Regouski, M., Van Wettere, A., Leir, S., Harris, A., White, K.L, Polejaeva, I., (2024). Towards Genetic Correction of Meconium Ileus by Intestinal Expression of CFTR in CFTR-null Sheep Model. Cystic Fibrosis Foundation 2024 Research Conference
• Perisse, I.V, Fan, Z., Liu, Y., Regouski, M., Van Wettere, A., Wang, Z., Harris, A., White, K.L, Polejaeva, I., (2019). Towards the correction of meconium ileus with cystic fibrosis transmembrane conductance regulator (CFTR) intestinal expression in CFTR knockout sheep. Reproduction, Fertility and Development
• Wilson, D., Baldwin, T.J, Kelly, E., Van Wettere, A., Hullinger, G., (2015). Bovine Viral Diarrhea diagnostic testing results in the Intermountain West- comparison between test methods, age, sex and beef vs. dairy breeds. American Dairy Science Association

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Book Chapters

• Van Wettere, A., Brown, D.L, (2022). Hepatobiliary System and Exocrine Pancreas : Pathologic Basis of Veterinary Disease, 6th Edition. . Elsevier - Mosby *
• Van Wettere, A., (2020). Avian Chlamydiosis: Merck Veterinary Manual. 12th ed. . Merck publishing
• Van Wettere, A., (2020). Bloodborne Organisms in Poultry: Merck Veterinary Manual. 12th ed. Merck publishing
• Van Wettere, A., (2020). Disorder of the Skeletal System in Poultry: Merck Veterinary Manual. 12th ed. Merck publishing
• Van Wettere, A., (2020). Myopathies in poultry: Merck Veterinary Manual. 12th ed. . Merck publishing
• Van Wettere, A., (2018). Histologic Patterns of Hepatotoxic Injury: Comprehensive Toxicology, 3th Edition. . Elsevier Science *
• Brown, D.L, Van Wettere, A., Cullen, J.M, (2016). Hepatobiliary System and Exocrine Pancreas : Pathologic Basis of Veterinary Disease, 6th Edition. . Elsevier - Mosby *
• Van Wettere, A., (2016). Disorder of the Skeletal System in Poultry: Merck Veterinary Manual. 11th ed. Merck publishing
• Van Wettere, A., (2016). Avian Chlamydiosis: Merck Veterinary Manual. 11th ed. . Merck publishing
• Van Wettere, A., (2016). Bloodborne Organisms in Poultry: Merck Veterinary Manual. 11th ed. Merck publishing

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Fact Sheets

• Frame, D., Van Wettere, A., (2015). Collection Procedure for Submitting PCR Samples to Utah Veterinary Diagnostic Laboratory for Avian Influenza Testing in Turkeys, Chickens, and Game Birds. *

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

• Leir, S., Tkachenko, S., Paranjapye, A., Van Wettere, A., Kerschner, J., Perisse, I.V, Marriott, C., Patrick, T., Liu, Y., White, K.L, Polejaeva, I., Harris, A., (2025). Cellular imbalance in proximal and distal lung of CFTR-/- sheep in utero and at birth.. Molecular Medicine, 31, 231 (2025), doi: https://doi.org/10.1186/s10020-025-01266-7
• Van Wettere, A., (2024). SARS-CoV-2 delta variant in African lions (Panthera leo) and humans at Utah's Hogle Zoo, USA, 2021–22. Zoonoses and Public Health, 71:7, 807-816. doi: 10.1111/zph.13156
• Gibson, S.A, Liu, Y., Li, R., Hurst, B., Fan, Z., Siddharthan, V., Larson, D.P, Sheesley, A.Y, Stewart, R., Kunzler, M., Polejaeva, I., Van Wettere, A., Moisyadi, S., Morrey, J.D, Tarbet, B., Wang, Z., (2024). Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines. Viruses, 16:10, doi: 10.3390/v16101625
• Leir, S., Tkachenko, S., Paranjapye, ., Meckler, F., Van Wettere, A., Kerschner, J.L, Kuznetsov, E., Schacht, M., Gillurkar, ., Regouski, M., Perisse, I.V, Marriott, C.M, Liu, Y., Bunderson, I., White, K.L, Polejaeva, I., Harris, A., (2024). Stellate cells are in utero markers of pancreatic disease in cystic fibrosis.. Molecular Medicine, 30, 115.
• Westover, J.B, Jung, K., Alkan, C., Boardman, K.M, Van Wettere, A., Martens, C., Rojas, I., Hicks, P., Thomas, A., Sandaine, M.T, Bluemling, G.R, Mao, S., Kolykhalov, A.A, Natchus, M.G, Bates, P., Painter, G.R, Gowen, B., (2024). Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine. Journal of Virology, 98, e00132-24. doi: https://doi.org/10.1128/jvi.00112-24
• Roug, A., Engebretsen, K., Van Wettere, A., Young, J.K, (2023). Disease Surveillance of Cougars (Puma concolor) in Utah, USA. Journal of Wildlife Diseases, 59:1, doi: 10.7589/jwd-d-22-00080
• Rodriguez, D.M, Hintze, K.J, Rompato, G., Stewart, E.C, Barton, A., Mortensen, E., Green, P.A, Van Wettere, A., Thomas, A., Benninghoff, A.D, (2023). Basal diet fed to recipient mice was the driving factor for colitis and colon tumorigenesis, despite fecal microbiota transfer from mice with severe or mild disease. Nutrients, 15:6, 1338. doi: 10.3390/nu15061338
• Peterson, C.J, Hurst, B., Evans, W., Van Wettere, A., Gibson, S.A, Smee, D.F, Tarbet, B., (2023). Human IVIG treatment in a neurological disease model for Enterovirus A71 infection in 28-day-old AG129 mice. Virology580, 62-72. doi: 10.1016/j.virol.2023.02.002
• Van Wettere, A., Leir, S.H, Cotton, C.U, Regouski, M., Perisse, I.V, Kerschner, J.L, Paranjapye, A., Fan, Z., Liu, Y., Schacht, M., White, K.L, Polejaeva, I., Harris, A., (2023). Early developmental phenotypes in the cystic fibrosis sheep model.. FASEB bioAdvances, 5:1, 13-26.
• Davies, C.J, Fan, Z., Morgado, K.P, Liu, Y., Regouski, M., Meng, Q., Thomas, A.J, Yun, S., Song, B., Frank, J.C, Perisse, I.V, Van Wettere, A., Lee, Y., Polejaeva, I.A, (2022). Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling. Frontiers in Genetics, 13, doi: 10.3389/fgene.2022.986316
• Davies, C.J, Fan, Z., Morgado, .P, Liu, Y., Regouski, M., Meng, Q., Thomas, A.J, Yun, S., Byung-Hak, B., Frank, J.C, Perisse, I.V, Van Wettere, A., Lee, Y., Polejaeva, I., (2022). Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling. Frontiers in Genetics, 13, 986316. doi: 10.3389/fgene.2022.986316
• Clayton, M., Kelly, E., Mainenti, M., Wilhelm, A., Torchetti, M.K, Kilian, M.L, Van Wettere, A., (2022). Pandemic lineage 2009 H1N1 influenza A virus infection in farmed mink in Utah. Journal of Veterinary Diagnostic Investigation, 34:1, 82-85.
• Roug, A., Shannon, J., Hersey, K., Heaton, W., Van Wettere, A., (2022). Investigation into Causes of Antler Deformities in Mule Deer (Odocoileus hemionus) Bucks in Southern Utah, USA.. Journal of Wildlife Diseases, 58:1, doi: 10.7589/jwd-d-21-00079
• Perisse, I.V, Fan, Z., Van Wettere, A., Liu, Y., Leir, S., Keim, J., Regouski, M., Wilson, M.D, Cholewa, K.M, Mansbach, S.N, Kelley, T.J, Wang, Z., Harris, A., White, K.L, Polejaeva, I., (2021). Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics. FASEB BioAdvances, 3:10, 841.
• Viotti Perisse, I., Fan, Z., Van Wettere, A., Liu, Y., Leir, S., Keim, J., Regouski, M., Wilson, M.D, Cholewa, K.M, Mansbach, S.N, Kelley, T.J, Wang, Z., Harris, A., White, K.L, Polejaeva, I.A, (2021). Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics. FASEB BioAdvances, 3:10, 841-854. doi: 10.1096/fba.2021-00043
• Hickerson, B.T, Sefing, E.J, Bailey, K.W, Van Wettere, A.J, Penichet, M.L, Gowen, B., (2020). Type I interferon underlies severe disease associated with Junín virus infection in mice. eLife, 9, e55325. doi: 10.7554/eLife.55352
• Neuman-Lee, L.A, Van Wettere, A., French, S., (2019). Interrelations among Multiple Metrics of Immune and Physiological Function in a Squamate, the Common Gartersnake (Thamnophis sirtalis).. Physiological and biochemical zoology : PBZ, 92:1, 12-23.
• Clancy, C.S, Van Wettere, A., Morrey, J.D, Julander, J., (2018). Coitus-Free Sexual Transmission of Zika Virus in a Mouse Model.. Scientific reports, 8:1, 15379.
• Fan, Z., Perisse, I.V, Cotton, C.U, Regouski, M., Meng, Q., Domb, C., Van Wettere, A., Wang, Z., Harris, A., White, K.L, Polejaeva, I., (2018). A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene. JCI Insight, 3:19, doi: 10.1172/jci.insight.123529
• Van Wettere, A., Jacqueline, K., Wilheim, A., Ipsen, J., (2018). Opisthotonos and unilateral internal hydrocephalus associated with aberrant migration of Serratospiculum spp. in a prairie falcon . Journal of Veterinary Diagnostic Investigation, 30:5, 770-773.
• Clancy, C.S, Van Wettere, A., Hullinger, G.A, (2018). Intracranial, extraneural ectopic lymph node in a bovine (Bos taurus).. Anatomia, histologia, embryologia, 47:4, 385-388.
• Julander, J., Siddharthan, V., Park, A.H, Preston, E., Mathur, P., Bertolio, M., Wang, H., Zukor, K., Van Wettere, A., Sinex, D.G, Morrey, J.D, (2018). Consequences of in utero exposure to Zika virus in offspring of AG129 mice.. Scientific reports, 8:1, 9384.
• Clancy, C.S, Van Wettere, A., Siddharthan, V., Morrey, J.D, Julander, J., (2018). Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar−/− Mice. The American Journal of Pathology, 188:4, 904 - 915.
• Clancy, C., Jensen, K., Van Wettere, A., (2018). Congenital Short Bowel Syndrome in an Adult Dog: A Case Report and Review of Literature.. Veterinary Pathology, 55:3, 462-465.
• Kurz, J.P, Schoenhals, K.E, Hullinger, G.A, Van Wettere, A., (2018). Syringomyelia in an Adult American Paint Horse.. Veterinary Sciences, 5:2, 39. doi: 10.3390/vetsci5020039
• Morrey, J., Wang, H., Hurst, B., Zukor, K., Siddharthan, V., Van Wettere, A., Sinex, D., Tarbet, E., (2018). Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice. Viruses, 10:1, 33. doi: 10.3390/v10010033
• Gowen, B., Westover, J.B, Sefing, E.J, Van Wettere, A., Bailey, K.W, Wandersee, L., Komeno, T., Furuta, Y., (2017). Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy. Antiviral Research
• Murray, M., Guo, J., Tizard, I., Jennings, S., Shivaprasad, H.L, Payne, S., Ellis, J.C, Van Wettere, A., O'Brien, K.M, (2017). Aquatic Bird Bornavirus-Associated Disease in Free-Living Canada Geese ( Branta canadensis ) in the Northeastern USA.. Journal of wildlife diseases, 53:3, 607-611.
• Siddharthan, V., Van Wettere, A., Li , R., Miao, J., Wang, Z., Morrey, J.D, Julander, J., (2017). Zika virus infection of adult and fetal STAT2 knock-out hamsters.. Virology, 507, 89-95.
• Wang, H., Hurst, B.L, Siddharthan, V., Van Wettere, A., Pilowsky, P.M, Morrey, J.D, (2017). Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters. Journal of NeuroVirology, 23:2, 186-204. doi: 10.1007/s13365-016-0488-6
• Zukor, K., Wang, H., Hurst, B.L, Siddharthan, V., Van Wettere, A., Pilowsky, P.M, Morrey, J.D, (2017). Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters. Journal of Neurovirology, 23:2, 186-204.
• Wilson, D., Baldwin, T.J, Wilhelm, A., Whitehouse, C.H, Bunnell, J.L, Rood, K., Van Wettere, A., (2017). Estimation of the trichomonad concentration in beef bull preputial samples and resultant population effect of pooling on detection of Tritrichomonas foetus using qPCR. Journal of Veterinary Science and Technology, 8:2, 1-3.
• Hill, R.J, Clement, H., Yeip, G., Merchant, S.S, Olsen, A.L, Stott, R.D, Van Wettere, A., Bressel, E., Mason, J., (2017). The Influence of Oblique Angle Forced Exercise in Surgically Destabilized Stifle Joints Is Synergistic with Bone, but Antagonistic with Cartilage in an Ovine Model of Osteoarthritis. Arthritis, doi: 10.1155/2017/7481619
• Julander, J.G, Siddharthan, V., Evans, J., Taylor, R., Tolbert, K., Apuli, C., Stewart, J., Collins, P., Gebre, M., Neilson, S., Van Wettere, A., Lee, Y., Sheridan, W.P, Morrey, J.D, Babu, Y., (2017). Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model. Antiviral Research, 137, 14-22. doi: 10.1016/j.antiviral.2016.11.003
• Gowen, B., Westover, J.B, Miao, J., Van Wettere, A., Rigas, J., Hickerson, B.T, Jung, K.H, Li, R., Conrad, B.L, Nielson, S., Furuta, Y., Wang, Z., (2017). Modeling severe fever with thrombocytopenia syndrome virus infection in golden Syrian hamsters: Importance of STAT2 in preventing disease and effective treatment with favipiravir. Journal of Virology
• Polejaeva, I., Ranjan, R., Davies, C., Regouski, M., Hall, J., Olsen, A.L, Meng, Q., Rutigliano, H., Dosdall, D., Angel, N., Sachse, F., Seidel, T., Thomas, A., Stott, R.D, Panter, K., Lee, P., Van Wettere, A., Stevens, J.R, Wang, Z., MacLeod, R., Marrouche, N., White, K.L, (2016). Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-β1. Journal of Cardiovascular Electrophysiology. , 27:10, 1220-1229.
• Roug, A., Clancy, C.S, Detterich, C., Van Wettere, A., (2016). Cerebral Larva Migrans Caused by Baylisascaris spp. in a Free-ranging North American Porcupine ( Erethizon dorsatum ).. Journal of wildlife diseases, 52:3, 763-5.
• Dombrowski, D.S, Vanderklok, C., Van Wettere, A., (2016). Curative surgical excision of a squamous cell carcinoma associated with the digit of an american bullfrog, lithobates catesbeianus (shaw, 1802). . J. Herpetol. Med. Surg.
• Wilson, D., Baldwin, T.J, Kelly, E., Van Wettere, A., Hullinger, G., Bunnell, J., (2016). Prevalence of Bovine Viral Diarrhea virus in bovine samples from the Intermountain West of the U.S.A. - comparison between age, sex, breed and diagnostic methods. Journal of Veterinary Science and Technology, 7:3, 1-4.
• George, J., Van Wettere, A., Michaels, B.B, Crain, D., Lewbart, G.A, (2016). Histopathologic evaluation of postmortem autolytic changes in bluegill (Lepomis macrohirus) and crappie (Pomoxis anularis) at varied time intervals and storage temperatures.. PeerJ, 4, e1943.
• Westover, J.B, Sefing, E.J, Bailey, K.W, Van Wettere, A., Jung, K., Dagley, A., Wandersee, L., Downs, B., Smee, D., Furuta, Y., Bray, M., Gowen, B., (2016). Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses. Antiviral Research
• Clancy, C.S, Roug, A., Armien, A.G, Van Wettere, A., (2016). Intracerebral Malignant Plasmacytoma in a Mule Deer (Odocoileus hemionus).. Journal of comparative pathology, 154:2-3, 268-71.
• Frame, D., Kelly, E., Van Wettere, A., (2015). Cardiomyopathy in Rio Grande Subspecies of Wild Turkey (Meleagris gallopavo) in Southern Utah, USA, 2013. Journal of Wildlife Diseases, 51 (3), 790-792.
• Frame, D.D, Kelly, E.J, Van Wettere, A., (2015). Dilated Cardiomyopathy in a Rio Grande Wild Turkey (<i>Meleagris gallopavo intermedia</i>) in Southern Utah, USA, 2013. Journal of Wildlife Diseases, 51:3, 790-792. doi: 10.7589/2014-09-228
• Scharton, D., Van Wettere, A., Bailey, K.W, Vest, Z., Westover, J.B, Siddharthan, V., Gowen, B., (2015). Rift Valley Fever Virus Infection in Golden Syrian Hamsters. PLoS ONE, 10:1, e0116722.
• Dagley, A., Ennis, J., Turner, J.D, Rood, K., Van Wettere, A., Gowen, B., Julander, J., (2014). Protection against Chikungunya virus induced arthralgia following prophylactic treatment with adenovirus vectored interferon (mDEF201). Antiviral Research, 108, 1-9. doi: 10.1016/j.antiviral.2014.05.004
• Julander, J., Kesler, K., Van Wettere, A., Morrey, J.D, Smee, D., (2014). The use of plethysmography in determining the severity of lung pathology in a mouse model of minimally lethal influenza virus infection. Antiviral Research, 108, 10-13. doi: 10.1016/j.antiviral.2014.05.002
• Julander, J.G, Kesler, K., Van Wettere, A., Morrey, J.D, Smee, D., (2014). The use of plethysmography in determining the severity of lung pathology in a mouse model of minimally lethal influenza virus infection. Antiviral Research, 108, 10-13.
• Scharton, D., Bailey, K.W, Vest, Z., Westover, J.B, Kumaki, Y., Van Wettere, A., Furuta, Y., Gowen, B.B, (2014). Favipiravir (T-705) protects against peracute Rift Valley fever virus infection and reduces delayed-onset neurologic disease observed with ribavirin treatment. Antiviral Research, 104, 84-92. doi: 10.1016/j.antiviral.2014.01.016
• Ip, H.S, Van Wettere, A., McFarlane, L., Shearn-Bochsler, V., Dickson, S.L, Baker, J., Hatch, G., Cavender, K.B, Long, R., Bodenstein, B., (2013). West Nile Virus Transmission in Winter: The 2013 Great Salt Lake Bald Eagle and Eared Grebes Mortality Event. PLoS currents, 6
• Sefing, E.J, Wong, M., Larson, D.P, Hurst, B.L, Van Wettere, A., Schneller, S.W, Gowen, B., (2013). Vascular leak ensues a vigorous proinflammatory cytokine response to Tacaribe arenavirus infection in AG129 mice. Virology Journal, 10, 221.
• Van Wettere, A., Lewbart, G.A, (2007). Cytologic Diagnosis of Diseases of Invertebrates. Veterinary Clinics of North America: Exotic Animal Practice, 10:1, 235-254. doi: 10.1016/j.cvex.2006.11.003
• Van Wettere, A., (2005). Malaria in an Eastern Screech Owl (Otus asio). Avian Diseases, 49:3, 433-435. doi: 10.1637/7318-122904r.1
• Van Wettere, A., (2005). Pathologic and Immunohistochemical Findings in Goshawks (Accipiter gentilis) and Great Horned Owls (Bubo virginianus) Naturally Infected with West Nile Virus. Avian Diseases, 49:2, 252-259. doi: 10.1637/7297-103104r

Professional Journal

• Mason, J., Gurda, B.L, Van Wettere, A., Engiles, J.B, Wilson, J., Richardson, D.W, (2017). Delivery and evaluation of recombinant adeno-associated viral vectors in the equine distal extremity for the treatment of laminitis.. Equine veterinary journal, 49:1, 79-86.
• Mason, J., Gurda, B.L, Van Wettere, A., Engiles, J.B, Wilson, J.M, Richardson, D.W, (2015). Delivery and evaluation of recombinant adeno-associated viral vectors in the equine distal extremity for the treatment of laminitis. Equine Veterinary Journal, doi: 10.1111/evj. 12547
• Frame, D., Kelly, E., Van Wettere, A., (2015). DILATED CARDIOMYOPATHY IN RIO GRANDE SUBSPECIES OF WILD TURKEY (MELEAGRIS GALLOPAVO). Journal of Wildlife Diseases

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.